FDA Approves Novel Obesity Treatment Zepbound

The U.S. Food and Drug Administration has recently approved a new drug, Zepbound (tirzepatide), for chronic weight management.

This medication is indicated for adults with obesity or those overweight with additional weight-related conditions such as hypertension, type 2 diabetes, or high cholesterol.

Zepbound, which requires a prescription, should be used in conjunction with a reduced-calorie diet and increased physical activity​​.

A Significant Development in Weight Management

The approval of Zepbound marks a significant advancement in the fight against obesity—a condition linked with major causes of death including heart disease, stroke, and diabetes. With obesity rates on the rise in the United States, Zepbound provides a new option for medical intervention​.

Zepbound operates by targeting hormones that regulate hunger and food intake, specifically GLP-1 and GIP.

It is administered via subcutaneous injection once a week, with a gradual dosage increase necessary to reach the full therapeutic effect.

Clinical Trials and Effectiveness

FDA approves a new weight loss drug
Photo by: ELI LILLY

Clinical trials have demonstrated its efficacy, with participants achieving an average weight loss of 12% to 18% over a 72-week period​.

The drug’s performance was evaluated in double-blind studies involving over 2,500 patients.

Those who received Zepbound showed a statistically significant weight reduction when compared to the placebo group, and a considerable number of participants achieved more than a 5% reduction in body weight​.

Safety and Side Effects

Despite its effectiveness, Zepbound comes with potential side effects including nausea, diarrhea, and vomiting.

It is also associated with risks such as thyroid C-cell tumors in rats, although it’s unclear if this extends to humans. Therefore, it should not be used by individuals with certain medical histories, including medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2​.

Zepbound represents a promising new treatment option for individuals struggling with weight management. Its approval by the FDA underscores the growing need for effective obesity treatments in the healthcare landscape.

With information from FDA and STAT News

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